
The results were evaluated in terms of total polyphenol yield (Y TP), total flavonoid yield (Y TF) and antiradical activity (A AR). Screening of NADES type, temperature, and particle size were investigated using one-pot-at-a-time method while, NADES amount and liquid-to-solid ratio were optimized using experimental design. New generation green solvents, natural deep eutectic solvents (NADES) were used in combination with ultrasound assisted extraction.

In this study, extraction of the bioactive compounds from olive leaves was conducted using a non-conventional and green method.

Lately the major component, oleuropein, has gained extra attention due to the anti-viral activity against SARS-CoV-2 that causes Coronavirus disease (Covid-19). Olive leaf as an agricultural waste contains valuable bioactive compounds that are mainly used for pharmaceutical and cosmetic industries.
